:root {
  --bg: oklch(0.15 0.008 240);
  --bg-2: oklch(0.19 0.012 240);
  --bg-3: oklch(0.23 0.015 240);
  --line: oklch(0.32 0.015 240);
  --line-2: oklch(0.40 0.02 240);
  --fg: oklch(0.94 0.008 240);
  --fg-dim: oklch(0.72 0.012 240);
  --fg-mute: oklch(0.55 0.012 240);
  --accent: oklch(0.82 0.14 180);
  --accent-dim: oklch(0.55 0.10 180);
  --warn: oklch(0.80 0.16 70);
  --danger: oklch(0.70 0.20 25);
  --good: oklch(0.82 0.18 150);
  --purple: oklch(0.72 0.14 300);
}

* { box-sizing: border-box; }
html, body { margin: 0; padding: 0; }
body {
  background: var(--bg);
  color: var(--fg);
  font-family: 'Inter', system-ui, sans-serif;
  font-size: 13px;
  line-height: 1.45;
  min-height: 100vh;
  overflow-x: hidden;
}
.mono { font-family: 'JetBrains Mono', ui-monospace, monospace; }
.tabular { font-variant-numeric: tabular-nums; }

.app {
  display: grid;
  grid-template-columns: 320px 1fr 360px;
  grid-template-rows: 52px 1fr;
  height: 100vh;
  gap: 1px;
  background: var(--line);
}

/* Header */
.topbar {
  grid-column: 1 / -1;
  background: var(--bg-2);
  display: flex;
  align-items: center;
  padding: 0 16px;
  gap: 24px;
  border-bottom: 1px solid var(--line);
}
.logo {
  display: flex;
  align-items: center;
  gap: 10px;
  font-family: 'JetBrains Mono', monospace;
  font-size: 12px;
  letter-spacing: 0.08em;
  text-transform: uppercase;
}
.logo-mark {
  width: 22px; height: 22px;
  border: 1px solid var(--accent);
  position: relative;
  transform: rotate(45deg);
}
.logo-mark::after {
  content: '';
  position: absolute;
  inset: 3px;
  background: var(--accent);
  opacity: 0.6;
}
.topbar .meta { margin-left: auto; display: flex; gap: 20px; font-family: 'JetBrains Mono', monospace; font-size: 11px; color: var(--fg-dim); }
.topbar .meta span b { color: var(--fg); font-weight: 500; }
.status-dot {
  display: inline-block;
  width: 7px; height: 7px;
  border-radius: 50%;
  background: var(--accent);
  margin-right: 6px;
  box-shadow: 0 0 8px var(--accent);
  animation: pulse 2s infinite;
}
@keyframes pulse { 50% { opacity: 0.4; } }

/* Panels */
.panel {
  background: var(--bg);
  overflow-y: auto;
  overflow-x: hidden;
}
.panel-left { border-right: 0; }
.panel-right { border-left: 0; }

.section {
  border-bottom: 1px solid var(--line);
  padding: 16px;
}
.section-title {
  font-family: 'JetBrains Mono', monospace;
  font-size: 10px;
  letter-spacing: 0.12em;
  text-transform: uppercase;
  color: var(--fg-mute);
  margin: 0 0 12px 0;
  display: flex;
  align-items: center;
  gap: 8px;
}
.section-title::before {
  content: '';
  width: 10px;
  height: 1px;
  background: var(--accent);
}
.section-title .count {
  margin-left: auto;
  color: var(--fg-mute);
  background: var(--bg-2);
  border: 1px solid var(--line);
  padding: 2px 6px;
  border-radius: 2px;
}

/* Cancer cards */
.cancer-list { display: flex; flex-direction: column; gap: 6px; }
.cancer-card {
  border: 1px solid var(--line);
  background: var(--bg-2);
  padding: 10px 12px;
  cursor: pointer;
  transition: all 0.15s ease;
  position: relative;
}
.cancer-card:hover { border-color: var(--line-2); background: var(--bg-3); }
.cancer-card.active {
  border-color: var(--accent);
  background: linear-gradient(90deg, color-mix(in oklch, var(--accent) 12%, var(--bg-2)), var(--bg-2));
}
.cancer-card.active::before {
  content: '';
  position: absolute;
  left: 0; top: 0; bottom: 0;
  width: 2px;
  background: var(--accent);
}
.cancer-card .cname {
  font-size: 13px;
  font-weight: 500;
  display: flex;
  justify-content: space-between;
  align-items: baseline;
}
.cancer-card .cshort {
  font-family: 'JetBrains Mono', monospace;
  font-size: 10px;
  color: var(--fg-mute);
}
.cancer-card .cmeta {
  font-family: 'JetBrains Mono', monospace;
  font-size: 10px;
  color: var(--fg-dim);
  margin-top: 4px;
  display: flex;
  gap: 12px;
}

/* Target table */
.target-row {
  display: grid;
  grid-template-columns: 1fr auto;
  padding: 8px 10px;
  border: 1px solid var(--line);
  background: var(--bg-2);
  margin-bottom: 4px;
  cursor: pointer;
  transition: all 0.12s;
  align-items: center;
}
.target-row:hover { border-color: var(--line-2); }
.target-row.active { border-color: var(--accent); background: color-mix(in oklch, var(--accent) 10%, var(--bg-2)); }
.target-row .gene {
  font-family: 'JetBrains Mono', monospace;
  font-size: 13px;
  font-weight: 500;
}
.target-row .locus {
  font-family: 'JetBrains Mono', monospace;
  font-size: 10px;
  color: var(--fg-mute);
  margin-top: 2px;
}
.target-row .strategy-badge {
  font-family: 'JetBrains Mono', monospace;
  font-size: 9px;
  padding: 2px 6px;
  border: 1px solid var(--line-2);
  text-transform: uppercase;
  letter-spacing: 0.06em;
}
.strategy-knockout { color: var(--danger); border-color: color-mix(in oklch, var(--danger) 40%, var(--line-2)); }
.strategy-silencing { color: var(--warn); border-color: color-mix(in oklch, var(--warn) 40%, var(--line-2)); }
.strategy-activation { color: var(--good); border-color: color-mix(in oklch, var(--good) 40%, var(--line-2)); }

.target-freq {
  height: 3px;
  background: var(--bg-3);
  margin-top: 6px;
  position: relative;
}
.target-freq > div {
  height: 100%;
  background: var(--accent);
}

/* Central stage */
.stage {
  display: grid;
  grid-template-rows: auto 1fr auto;
  background: var(--bg);
  position: relative;
}
.stage-header {
  padding: 16px 24px;
  border-bottom: 1px solid var(--line);
  display: flex;
  justify-content: space-between;
  align-items: flex-end;
  gap: 24px;
}
.stage-title-block h1 {
  margin: 0;
  font-size: 22px;
  font-weight: 600;
  letter-spacing: -0.01em;
}
.stage-title-block .sub {
  font-family: 'JetBrains Mono', monospace;
  font-size: 11px;
  color: var(--fg-dim);
  margin-top: 4px;
}
.stage-title-block .blurb {
  font-size: 12px;
  color: var(--fg-dim);
  margin-top: 8px;
  max-width: 680px;
}

.stage-body {
  display: grid;
  grid-template-columns: 1.1fr 1fr;
  gap: 1px;
  background: var(--line);
  overflow: hidden;
}

.stage-cell {
  background: var(--bg);
  padding: 16px 20px;
  overflow: hidden;
  display: flex;
  flex-direction: column;
  min-height: 0;
}
.cell-title {
  font-family: 'JetBrains Mono', monospace;
  font-size: 10px;
  letter-spacing: 0.12em;
  text-transform: uppercase;
  color: var(--fg-mute);
  margin-bottom: 12px;
  display: flex;
  align-items: center;
  gap: 8px;
}
.cell-title .hint { margin-left: auto; color: var(--fg-mute); font-size: 10px; text-transform: none; letter-spacing: 0; }

/* Cell grid (tumor viz) */
.tumor-wrap { flex: 1; min-height: 0; display: flex; flex-direction: column; gap: 10px; }
.tumor-grid {
  flex: 1;
  display: grid;
  gap: 1px;
  min-height: 0;
  position: relative;
}
.tumor-cell {
  background: oklch(0.60 0.12 25);
  border-radius: 1px;
  transition: background 0.4s ease, transform 0.3s ease;
  position: relative;
}
/* Per-cell PAM-cytosine methylation buckets (β-value visualization) */
.tumor-cell[data-state="cell-hypo"]   { background: oklch(0.55 0.10 150); } /* low β — editable */
.tumor-cell[data-state="cell-mid"]    { background: oklch(0.60 0.12 100); }
.tumor-cell[data-state="cell-mhi"]    { background: oklch(0.62 0.13 60);  }
.tumor-cell[data-state="cell-hyper"]  { background: oklch(0.62 0.14 30);  } /* hypermethylated — locked */
.tumor-cell[data-state="edited"]      { background: oklch(0.82 0.16 190); box-shadow: 0 0 4px color-mix(in oklch, var(--accent) 60%, transparent); }
.tumor-cell[data-state="dead"]        { background: oklch(0.25 0.01 240); opacity: 0.4; transform: scale(0.7); }

/* Dual-grid layout: cancer + normal cell-line panels side by side */
.dual-grid {
  display: grid;
  grid-template-columns: 1fr 1fr;
  gap: 12px;
  flex: 1;
  min-height: 0;
}
.line-panel {
  display: flex;
  flex-direction: column;
  gap: 8px;
  min-height: 0;
  border: 1px solid var(--line);
  background: var(--bg-2);
  padding: 10px;
}
.line-panel .tumor-grid { gap: 1px; }
.line-panel-head {
  display: flex;
  justify-content: space-between;
  align-items: flex-start;
  gap: 8px;
}
.ln-name {
  font-family: 'JetBrains Mono', monospace;
  font-size: 12px;
  font-weight: 500;
  color: var(--fg);
  display: flex;
  align-items: center;
  gap: 6px;
}
.ln-tag {
  font-size: 9px;
  padding: 1px 5px;
  border: 1px solid var(--line-2);
  text-transform: uppercase;
  letter-spacing: 0.06em;
  color: var(--fg-dim);
}
.ln-tag[data-kind="cancer"] { color: var(--good); border-color: color-mix(in oklch, var(--good) 50%, var(--line-2)); }
.ln-tag[data-kind="normal"] { color: var(--warn); border-color: color-mix(in oklch, var(--warn) 50%, var(--line-2)); }
.ln-sub {
  font-size: 10px;
  color: var(--fg-mute);
  margin-top: 2px;
}
.ln-beta {
  font-family: 'JetBrains Mono', monospace;
  font-size: 11px;
  color: var(--fg-mute);
}
.ln-beta b { color: var(--accent); font-weight: 500; }

/* SEO content block — visible to crawlers, lower-density layout for the body */
.seo-content {
  max-width: 920px;
  margin: 24px auto 80px;
  padding: 0 24px;
  font-size: 14px;
  line-height: 1.6;
  color: var(--fg-dim);
}
.seo-content h2 {
  font-size: 18px;
  color: var(--fg);
  margin-top: 32px;
  margin-bottom: 8px;
  font-weight: 600;
  letter-spacing: -0.005em;
}
.seo-content h3 {
  font-size: 14px;
  color: var(--fg);
  margin-top: 20px;
  margin-bottom: 6px;
  font-family: 'JetBrains Mono', monospace;
  text-transform: uppercase;
  letter-spacing: 0.08em;
}
.seo-content p { margin: 8px 0; }
.seo-content a { color: var(--accent); text-decoration: none; border-bottom: 1px dotted var(--accent-dim); }
.seo-content a:hover { border-bottom-style: solid; }
.seo-content code {
  font-family: 'JetBrains Mono', monospace;
  font-size: 12px;
  background: var(--bg-2);
  padding: 1px 5px;
  border: 1px solid var(--line);
  color: var(--fg);
}
.seo-content .cite {
  font-size: 12px;
  color: var(--fg-mute);
  border-left: 2px solid var(--accent-dim);
  padding-left: 12px;
  margin: 16px 0;
}
.seo-content dl { margin: 8px 0; }
.seo-content dt { color: var(--fg); font-weight: 500; margin-top: 12px; }
.seo-content dd { margin: 4px 0 8px 0; }
.seo-footer {
  border-top: 1px solid var(--line);
  margin-top: 48px;
  padding: 20px 24px;
  font-size: 12px;
  color: var(--fg-mute);
  text-align: center;
}
.seo-footer a { color: var(--fg-dim); text-decoration: none; }
.seo-footer a:hover { color: var(--accent); }

.stats-row {
  display: grid;
  grid-template-columns: repeat(4, 1fr);
  gap: 1px;
  background: var(--line);
}
.stat {
  background: var(--bg-2);
  padding: 10px 12px;
}
.stat .label { font-family: 'JetBrains Mono', monospace; font-size: 9px; letter-spacing: 0.1em; text-transform: uppercase; color: var(--fg-mute); }
.stat .value { font-family: 'JetBrains Mono', monospace; font-size: 20px; font-weight: 500; margin-top: 2px; }
.stat .delta { font-family: 'JetBrains Mono', monospace; font-size: 10px; color: var(--fg-dim); }
.stat .value.accent { color: var(--accent); }
.stat .value.warn   { color: var(--warn); }
.stat .value.danger { color: var(--danger); }
.stat .value.good   { color: var(--good); }

/* Chart */
.chart-wrap { flex: 1; min-height: 0; position: relative; }
.chart-wrap svg { width: 100%; height: 100%; display: block; }
.axis-label { font-family: 'JetBrains Mono', monospace; font-size: 10px; fill: var(--fg-mute); }
.grid-line { stroke: var(--line); stroke-width: 1; }
.grid-line-soft { stroke: var(--bg-3); stroke-width: 1; }
.line-tumor { stroke: var(--danger); stroke-width: 2; fill: none; }
.area-tumor { fill: var(--danger); opacity: 0.08; }
.line-edited { stroke: var(--accent); stroke-width: 2; fill: none; }
.line-temp { stroke: var(--warn); stroke-width: 1.5; fill: none; stroke-dasharray: 3 3; }

/* Bottom controls */
.controls {
  border-top: 1px solid var(--line);
  background: var(--bg-2);
  padding: 14px 20px;
  display: grid;
  grid-template-columns: auto 1fr auto;
  align-items: center;
  gap: 20px;
}
.play-btn {
  width: 44px; height: 44px;
  border: 1px solid var(--accent);
  background: color-mix(in oklch, var(--accent) 15%, transparent);
  color: var(--accent);
  cursor: pointer;
  display: flex;
  align-items: center;
  justify-content: center;
  transition: all 0.15s;
}
.play-btn:hover { background: color-mix(in oklch, var(--accent) 25%, transparent); }
.play-btn svg { width: 16px; height: 16px; }

.timeline {
  flex: 1;
  position: relative;
}
.timeline-track {
  height: 4px;
  background: var(--bg-3);
  border: 1px solid var(--line);
  position: relative;
}
.timeline-fill {
  position: absolute;
  top: 0; left: 0; bottom: 0;
  background: var(--accent);
}
.timeline-head {
  position: absolute;
  top: -4px;
  width: 2px;
  height: 12px;
  background: var(--accent);
}
.timeline-ticks {
  margin-top: 6px;
  display: flex;
  justify-content: space-between;
  font-family: 'JetBrains Mono', monospace;
  font-size: 9px;
  color: var(--fg-mute);
}

.reset-btn, .btn {
  font-family: 'JetBrains Mono', monospace;
  font-size: 10px;
  letter-spacing: 0.1em;
  text-transform: uppercase;
  padding: 8px 14px;
  background: transparent;
  border: 1px solid var(--line-2);
  color: var(--fg-dim);
  cursor: pointer;
  transition: all 0.15s;
}
.btn:hover { border-color: var(--accent); color: var(--accent); }
.btn.primary { border-color: var(--accent); color: var(--accent); background: color-mix(in oklch, var(--accent) 10%, transparent); }
.btn.primary:hover { background: color-mix(in oklch, var(--accent) 20%, transparent); }

/* Right panel */
.mode-select {
  display: flex;
  flex-direction: column;
  gap: 4px;
}
.mode-opt {
  border: 1px solid var(--line);
  background: var(--bg-2);
  padding: 10px 12px;
  cursor: pointer;
  transition: all 0.12s;
}
.mode-opt:hover { border-color: var(--line-2); }
.mode-opt.active { border-color: var(--accent); background: color-mix(in oklch, var(--accent) 10%, var(--bg-2)); }
.mode-opt .mlabel { font-size: 12px; font-weight: 500; display: flex; justify-content: space-between; align-items: center; }
.mode-opt .mabbr  { font-family: 'JetBrains Mono', monospace; font-size: 9px; color: var(--accent); letter-spacing: 0.08em; }
.mode-opt .mdesc  { font-size: 11px; color: var(--fg-dim); margin-top: 4px; }

.delivery-select {
  display: grid;
  grid-template-columns: repeat(2, 1fr);
  gap: 4px;
}
.delivery-opt {
  border: 1px solid var(--line);
  background: var(--bg-2);
  padding: 8px 10px;
  cursor: pointer;
  text-align: left;
  color: var(--fg-dim);
  font-family: 'JetBrains Mono', monospace;
  font-size: 10px;
}
.delivery-opt:hover { border-color: var(--line-2); color: var(--fg); }
.delivery-opt.active { border-color: var(--accent); color: var(--accent); }
.delivery-opt .deff {
  display: block;
  color: var(--fg-mute);
  font-size: 9px;
  margin-top: 2px;
}

/* Thermal slider */
.temp-block { display: flex; flex-direction: column; gap: 8px; }
.temp-readout {
  font-family: 'JetBrains Mono', monospace;
  font-size: 32px;
  font-weight: 300;
  color: var(--accent);
  line-height: 1;
}
.temp-readout .unit { font-size: 14px; color: var(--fg-mute); margin-left: 4px; }
.temp-subrow {
  display: flex;
  justify-content: space-between;
  font-family: 'JetBrains Mono', monospace;
  font-size: 10px;
  color: var(--fg-dim);
}

input[type=range] {
  -webkit-appearance: none;
  width: 100%;
  background: transparent;
  height: 20px;
}
input[type=range]::-webkit-slider-runnable-track {
  height: 4px;
  background: linear-gradient(90deg,
    oklch(0.40 0.02 240) 0%,
    oklch(0.40 0.02 240) 27%,
    oklch(0.80 0.16 70) 45%,
    oklch(0.82 0.14 180) 60%,
    oklch(0.80 0.16 70) 72%,
    oklch(0.50 0.10 25) 85%,
    oklch(0.40 0.02 240) 100%);
  border: 1px solid var(--line);
}
input[type=range]::-webkit-slider-thumb {
  -webkit-appearance: none;
  width: 12px; height: 16px;
  background: var(--fg);
  border: 1px solid var(--accent);
  margin-top: -7px;
  cursor: pointer;
}

/* Activity curve mini */
.curve-mini { height: 70px; margin-top: 4px; position: relative; }
.curve-mini svg { width: 100%; height: 100%; }
.curve-mini .legend {
  position: absolute;
  top: 0; right: 0;
  font-family: 'JetBrains Mono', monospace;
  font-size: 9px;
  display: flex;
  gap: 8px;
  color: var(--fg-mute);
}
.curve-mini .legend span { display: flex; align-items: center; gap: 4px; }
.curve-mini .legend i { width: 10px; height: 2px; display: inline-block; }

/* gRNA sequence */
.grna-block {
  font-family: 'JetBrains Mono', monospace;
  font-size: 11px;
  background: var(--bg-2);
  border: 1px solid var(--line);
  padding: 10px;
  overflow: hidden;
}
.grna-block .seq {
  word-break: break-all;
  line-height: 1.6;
}
.grna-block .nt { color: var(--fg); }
.grna-block .pam { color: var(--bg); background: var(--accent); padding: 1px 2px; }
.grna-block .label-row {
  display: flex;
  justify-content: space-between;
  font-size: 9px;
  color: var(--fg-mute);
  margin-bottom: 6px;
  letter-spacing: 0.08em;
  text-transform: uppercase;
}
.grna-block .tm {
  margin-top: 8px;
  display: flex;
  gap: 12px;
  font-size: 10px;
  color: var(--fg-dim);
}
.grna-block .tm b { color: var(--fg); font-weight: 500; }

/* Delivery flow */
.flow {
  display: grid;
  grid-template-columns: 1fr auto 1fr auto 1fr auto 1fr;
  align-items: center;
  gap: 6px;
  font-family: 'JetBrains Mono', monospace;
  font-size: 9px;
  color: var(--fg-dim);
  margin-top: 12px;
}
.flow .node {
  border: 1px solid var(--line-2);
  padding: 6px 8px;
  text-align: center;
  background: var(--bg-2);
  text-transform: uppercase;
  letter-spacing: 0.06em;
}
.flow .node.active { border-color: var(--accent); color: var(--accent); }
.flow .arr { color: var(--fg-mute); text-align: center; }

/* Tweaks */
.tweaks-panel {
  position: fixed;
  right: 20px;
  bottom: 20px;
  width: 280px;
  background: var(--bg-2);
  border: 1px solid var(--accent-dim);
  padding: 14px;
  z-index: 100;
  display: none;
  font-size: 12px;
}
.tweaks-panel.open { display: block; }
.tweaks-panel h4 {
  margin: 0 0 10px;
  font-family: 'JetBrains Mono', monospace;
  font-size: 10px;
  letter-spacing: 0.12em;
  text-transform: uppercase;
  color: var(--accent);
}
.tweak-row {
  display: flex;
  align-items: center;
  justify-content: space-between;
  padding: 6px 0;
  border-bottom: 1px solid var(--line);
  gap: 8px;
}
.tweak-row:last-child { border-bottom: 0; }
.tweak-row label { color: var(--fg-dim); font-size: 11px; }
.tweak-row select, .tweak-row input[type=number] {
  background: var(--bg);
  color: var(--fg);
  border: 1px solid var(--line-2);
  padding: 3px 6px;
  font-family: 'JetBrains Mono', monospace;
  font-size: 10px;
}

/* Scrollbars */
.panel::-webkit-scrollbar { width: 8px; }
.panel::-webkit-scrollbar-track { background: var(--bg); }
.panel::-webkit-scrollbar-thumb { background: var(--line-2); }

/* badges */
.role-pill {
  display: inline-block;
  font-family: 'JetBrains Mono', monospace;
  font-size: 9px;
  padding: 1px 5px;
  border-radius: 2px;
  color: var(--fg-dim);
  background: var(--bg-3);
  margin-right: 4px;
}

/* helix decoration */
.helix {
  position: absolute;
  pointer-events: none;
  opacity: 0.08;
  top: 0;
  right: 0;
  width: 200px;
  height: 100%;
}

/* DSB flash */
@keyframes dsb-flash {
  0%   { box-shadow: 0 0 0 0 color-mix(in oklch, var(--accent) 70%, transparent); }
  70%  { box-shadow: 0 0 6px 4px color-mix(in oklch, var(--accent) 0%, transparent); }
  100% { box-shadow: 0 0 0 0 transparent; }
}
.tumor-cell.editing {
  animation: dsb-flash 0.6s ease-out;
}

@media (max-width: 1200px) {
  .app { grid-template-columns: 260px 1fr 300px; }
  .stage-body { grid-template-columns: 1fr; grid-template-rows: 1fr 1fr; }
}